Studies of Nattokinase and Bromelain
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458005/ - National Library of Medicine (08/22)
SARS-CoV-2 has a spike protein (S protein) … Nattokinase is produced by Bacillus subtilis var. natto and is beneficial to human health. In this study, we examined the effect of nattokinase on the S protein of SARS-CoV-2. When cell lysates transfected with S protein were incubated with nattokinase, the S protein was degraded in a dose- and time-dependent manner. In this study, we showed that the protease activity of nattokinase contributes to the degradation of S protein.
Nattokinase and Spike Protein Inhibition – Agency for Healthcare Research and Quality (11/23)
The spike proteins the body is forced to produce following mRNA injections are shown to be present at least 15 months post injection. The mRNA injections also cause a variety of short- and long-term health complications, including suppressed immune system, increased vulnerability to the SARS-CoV-2 virus, blood clots, heart damage, increased risk of stroke, increased risk of cancer, and many others. Nattokinase has been shown to inhibit function of the spike protein. If taken for 4-5 months (long enough for all the infected blood cells to die), will patients recover from the injection, stop producing the spike protein, and lower their risk of other complications associated with the injections?
Population: Recipients of any generation or formulation of Pfizer's or Moderna's mRNA injections
Overall: What is the effectiveness of Nattokinase for recipients of the mRNA injections for helping their bodies recover from the injections?
If the spike protein can be prevented from infecting other cells, it may eventually get filtered out of their systems, allowing their body to start the recovery process.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663976/ - National Library of Medicine (11/23)
Clinical Approach to Post-acute Sequelae After COVID-19 Infection and Vaccination (excerpted)
The spike protein of SARS-CoV-2 has been found to exhibit pathogenic characteristics and be a possible cause of post-acute sequelae after SARS-CoV-2 infection or COVID-19 vaccination. COVID-19 vaccines utilize a modified, stabilized prefusion spike protein that may share similar toxic effects with its viral counterpart.
The aim of this study is to investigate possible mechanisms of harm to biological systems from SARS-CoV-2 (emerged in Dec. 2019) spike protein and vaccine-encoded spike protein and to propose possible mitigation strategies. We searched PubMed, Google Scholar, and ‘grey literature’ to find studies that (1) investigated the effects of the spike protein on biological systems, (2) helped differentiate between viral and vaccine-generated spike proteins, and (3) identified possible spike protein detoxification protocols and compounds that had signals of benefit and acceptable safety profiles. We found abundant evidence that SARS-CoV-2 spike protein may cause damage in the cardiovascular, hematological, neurological, respiratory, gastrointestinal, and immunological systems. Viral and vaccine-encoded spike proteins have been shown to play a direct role in cardiovascular and thrombotic injuries from both SARS-CoV-2 and vaccination.
Detection of spike protein for at least 6-15 months after vaccination and infection in those with post-acute sequelae indicates spike protein as a possible primary contributing factor to long COVID. We rationalized that these findings give support to the potential benefit of spike protein detoxification protocols in those with long-term post-infection and/or vaccine-induced complications. We propose a base spike detoxification protocol, composed of oral Nattokinase, bromelain, and curcumin. This approach holds immense promise as a base of clinical care, upon which additional therapeutic agents are applied with the goal of aiding in the resolution of post-acute sequelae after SARS-CoV-2 infection and COVID-19 vaccination.
To combat this virus, novel gene-based vaccines were developed that utilize viral vector (AstraZeneca; Johnson and Johnson) and mRNA (Moderna; Pfizer-BioNTech) platforms to encode for spike protein, which elicits an immune response that generates antibodies. The SARS-CoV-2 spike protein plays a critical role in the virus’s infection process. Mutations of the spike protein lead to new strains that can re-infect those who have already recovered from a previous SARS-CoV-2 variant. Most of the vaccines deployed to prevent COVID-19 illness utilize a full-length spike protein … .
Post-acute sequelae (long COVID) after SARS-CoV-2 infection or COVID-19 vaccination is characterized by new or persisting multi-system symptoms months to years after initial infection or vaccination. These symptoms can range from generalized anxiety disorder and difficulty concentrating to fatigue and muscle weakness. The true incidence and prevalence of long COVID after infection are not fully known, but it has been approximated to be quite common. It is been estimated that 50% of those who were infected with SARS-CoV-2 develop long COVID.
Research on the prevalence of post-COVID vaccination syndrome is limited; however, a prospective cohort study found that 52.8% of individuals developed post-COVID vaccination syndrome for at least one month after primary COVID-19 vaccination. In this study, the prevalence increased to 83.9% among those who received booster doses. A retrospective cross-sectional study found a post-COVID vaccination syndrome prevalence of 26.2% after COVID-19 vaccination, with higher rates seen in individuals who received Moderna vaccines compared to Pfizer vaccines. These data indicate that post-acute sequelae (persistent symptoms or signs; complications or conditions that arise as a direct result of a condition) after COVID-19 vaccination are clinically relevant.
Concerns have been raised that suggest spike protein is involved in various pathologies, including post-acute sequelae after SARS-CoV-2 infection and COVID-19 vaccination. This may be due to spike protein exhibiting harmful properties, including inflammation, endothelial tissue damage, and brain damage. Moreover, spike protein has been associated with thrombotic endothelialitis, endothelial inflammation, hyperactivated platelets, and fibrinaloid microclots in those with long COVID. Parry et al. found that spike protein is detrimental to many organ systems by analyzing autopsies and biopsies of spike-infected tissues. This is particularly relevant since COVID-19 vaccines work by using spike protein to trigger an immune response. The aim of this study is to investigate possible mechanisms of harm on biological systems from … vaccine-encoded spike protein for the purpose of exploring causes of COVID-19 … vaccine injury syndromes, and potential therapeutic strategies.
Results: Deleterious Effects of Spike Protein by Organ System
Cardiovascular system: The cardiovascular system has been identified as one of the primary targets of the SARS-CoV-2 spike protein. Disruptions in human cardiac pericytes, a type of cell that wraps around the endothelial cells of capillaries and venules, have been observed by the exposure of the spike protein. These disruptions include increased migration, secretion of inflammatory molecules that are seen in the cytokine storm, and creation of apoptotic factors that cause cell death. Furthermore, spike protein has been found to hinder mitochondrial functions in human cardiomyocytes, potentially leading to energy deficits and reduced cardiac output. This effect may be due to spike protein inducing negative mitochondrial membrane potential, increasing intracellular calcium, and increasing levels of reactive oxygen species (ROS). The spike protein may also induce cardiomyocyte fusion, which may amplify the risk of arrhythmias, and irregular heart rhythms that can be life-threatening. In this study, spike protein induced delayed depolarizations, altered beating frequency, and induced calcium influx problems. In the context of vaccination, there have been reports of spike protein's detection in patients diagnosed with COVID-19 vaccine-induced myocarditis (my added note from other research: myocarditis can present with ventricular tachycardia). From the available evidence, spike protein displays obvious toxic effects on the cardiovascular system.
[Side note: Catheter ablation cures SVT in 95-98% of cases]
The hematological system, which includes blood and its components, is also targeted by the spike protein. The protein has been shown to incite inflammation in endothelial cells. This inflammation can promote clot formation; adding to the toxic effects, spike protein may transform fibrin into a form that resists fibrinolysis, making it harder for the body to dissolve blood clots. The spike protein's affinity to bind competitively to heparan sulfate, an important glycoprotein involved in coagulation, further aggravates coagulation.
Neurological implications of the spike protein are particularly concerning. Spike protein has been demonstrated to compromise the blood-brain barrier's integrity, which can potentially allow harmful substances from the bloodstream to enter the brain. On a cellular level, there are indications of spike protein possibly causing deleterious changes in molecular delivery and metabolic functions in brain endothelial cells. Some experimental models even suggest that spike protein might be a contributing factor in long-term cognitive dysfunctions. These data indicate that spike protein exerts potent harmful effects on the neurological system by damaging blood-brain barrier function and destroying neurons.
Respiratory system: Spike protein also targets the respiratory system. Spike protein has been shown to stimulate inflammatory pathways in human lung cells. This inflammatory cascade occurred independent of the virus, indicating that spike protein may have been the sole cause.
Gastrointestinal system: The gastrointestinal tract is not immune to spike protein's effects either. By triggering increased permeability and inflammation, spike protein may lead to leakage of toxins into circulation, resulting in negative systemic effects.
Immunological system: Spike protein also exerts damaging effects on the immune system, particularly in monocytes, which are part of the innate immune system and are a type of white blood cell that helps destroy infected cells and regulate cellular homeostasis … This may lead to inflammatory conditions that cause multiple organ dysfunction. Concerningly, spike protein can persist in monocytes for an indefinite period of time. From the available data, it can be concluded that SARS-CoV-2 spike protein is detrimental to the immunological system by possibly causing long-term immune dysfunction.
Differentiating the SARS-CoV-2 Spike Protein from Vaccine-Generated Spike Protein
Vaccine-encoded spike protein differs from the viral version by the replacement of the amino acids lysine and valine with two or six proline amino acids, which stabilizes the spike conformation in an inactive prefusion state. The purpose of this stabilization is that it makes the spike protein more immunogenic than the viral version, thus making it more effective at inducing antibody production. Even though stabilized prefusion spike protein is effective at invoking an immune response, it may not be safer than its viral counterpart.
Brogna et al. found the stabilized prefusion spike protein in human subjects for up to six months after vaccination using mass spectrometry techniques. This extensive persistence of vaccine-generated spike protein in humans is also seen with COVID-19 infection spike protein. Perry et al. concluded that spike protein is pathogenic from both SARS-CoV-2 and vaccine mRNA. These data indicate that the stabilized prefusion spike proteins can persist in the human body, be difficult to break down by natural human mechanisms, and may possess similar harmful characteristics to the viral type.
Rationale for SARS-CoV-2 and COVID-19 Vaccine Spike Protein Detoxification
Given the deleterious effects of spike protein and its persistence in those with post-acute sequelae after SARS-CoV-2 infection and COVID-19 vaccination, strategies to eliminate spike protein from the human body may be warranted to reduce the burden of disease from COVID-19 and vaccine injury syndromes.
As revealed by autopsy, some severe COVID-19 vaccine injury syndromes that may be directly or indirectly caused by spike protein include sudden cardiac death, myocardial infarction, myocarditis, pericarditis, pulmonary embolism, vaccine-induced immune thrombotic thrombocytopenia, brain hemorrhage, multi-organ failure, respiratory failure, and cytokine storm.
Most of the injury syndromes involve cardiac and thrombotic events that have been associated with spike protein, revealing it as a prime target for treatment. At the time of writing, specific and widely established treatment protocols to remove spike protein from the human body are non-existent.
McCullough et al. recently published (2023) the first rationale for spike protein detoxification, called the McCullough protocol: base spike detoxification, that holds considerable promise. The protocol includes a natural triple-agent oral regimen of nattokinase, bromelain, and curcumin.
The full base spike detoxification protocol is as follows:
Bromelain 500 mg once a day, nattokinase 2,000 FU (100 mg) twice a day, and curcumin 500 mg twice a day. The regimen is to be followed for 3-12 months or more, depending on disease resolution progress. These are initial dosages and may be adjusted in accordance with the tolerability and severity of injury syndrome. Because doses are far below known limits of safety, dose escalation would be reasonable if there are residual symptoms after three months of therapy. If ANA is positive and an autoimmune disease is suspected, prescribed hydroxychloroquine 200 mg twice a day should be added to the regimen. If pleurodynia or atypical chest pain is present, prescribed colchicine 0.6 mg once a day should be used in addition.
Conclusions: We found abundant evidence that SARS-CoV-2 spike protein may cause biological damage in the cardiovascular, hematological, neurological, respiratory, gastrointestinal, and immunological systems.
Mechanistically, spike protein has been shown to cause dysfunction in many cell types by causing metabolic deteriorations, leading to cell death. Stabilized prefusion (vaccine-derived) spike protein may possess similar harmful mechanisms as viral spike protein. Vaccine-derived and viral spike proteins have been found in humans for at least 6-15 months after vaccination or infection. More research is needed to further investigate the effect of spike protein in patients with post-acute sequelae after COVID-19 and COVID-19 vaccination. Meanwhile, the current data points to a strong signal to urgently develop spike protein detoxification protocols. There are currently no widely accepted protocols to do this in human subjects.
The McCullough protocol: base spike detoxification is the first protocol established to help remove spike protein derived from SARS-CoV-2 infection and vaccination in humans. The three-drug regimen of nattokinase, bromelain, and curcumin was chosen due to their proven safety records, as well as their anti-inflammatory and anti-coagulant properties combined with their synergistic and potent effects in degrading and inhibiting spike protein. This protocol may be useful in the attenuation of COVID-19 vaccine-induced injury syndromes and long-term COVID-19 complications.
The base spike detoxification protocol was devised based on the best evidence currently available. No therapeutic claims can be made until large-scale, prospective, randomized, double-blind, placebo-controlled trials are completed. On November 15, 2023, we searched clinicaltrials.gov and found no planned or ongoing trials with nattokinase or bromelain in the treatment of post-acute sequelae after COVID-19 or vaccination. Base spike detoxification is an important advancement in the development of testable hypotheses for future trials assessing treatments.
SARS-CoV-2 spike protein is a highly persistent, potentially pathogenic substance that may incite inflammation and tissue damage in almost all organ systems. The vaccine-generated spike protein is different from the viral type, but both have been associated with deleterious effects and persistence in biological systems. Base spike detoxification is a promising proposal designed to theoretically attenuate spike protein and its associated damage. Moreover, further investigation is essential to ensure vaccine-produced, stabilized prefusion spike protein safety and half-life in humans and that it does not possess the same deleterious effects as the viral spike protein.
For more information presented directly from Dr. Peter McCullough, watch the video House of Medicine on Fire … https://petermcculloughmd.substack.com/p/house-of-medicine-on-fire
My thanks to fellow tribe member Deborah Collins and others for “pointing me in the right direction” to ferret out this information! REMEMBER: This is NOT medical advice of any kind. This is research I did for ME, that I am sharing with the community in case anyone else is interested. I can tell you that after watching the video, and painfully digging through these research papers (I didn’t even take biology in high school or college), it has caused me to become extremely angry … not just because the vaccines were brought to market way too early – a case can be built that it was “for the greater good” but that I was literally forced to get the vaccine, or suddenly “retire early” … there was no discussion. Look at what our society devolved into – you couldn’t travel, go to restaurants, etc. unless you had the “golden ticket” (proof of vaccination), even given that it was brought to market so quickly.
Do we (anyone who has had COVID, or who has had the vaccinations/boosters) have spike proteins in our body – still – months/years after the last “interaction”? Who knows? But the initial research I’ve found (that certainly isn’t being promoted by any news media outlets) indicates there is a VERY good probability that we do. And I have come to the conclusion that my sudden case of SVT (supra ventricular tachycardia) discovered during a routine treadmill stress test at my cardiologist in late 2022, indicates to me that I should at least consider the possibility (probability???) that the vaccine gave me a “gift that keeps on giving!” Because after 40 years, and multiple stress tests, with each one I was told, “your heart will outlast you! You are good!” to suddenly come up with SVT is certainly eyebrow-raising, if not downright suspicious. Oh – by the way – I’m NOT one of those “everything is a conspiracy” persons. And yes, I DO believe we went to the moon and walked on the moon!
Good luck, good reading! I’d suggest you read my 5-page summary of these 3 articles, watch the Dr. Peter McCullough video, and then go look at the full papers. I did my best to only extract parts that were relevant to my research; but that’s me … not you. Whether you’ve had COVID or not, had COVID vaccines/boosters or not, this is worth your time to gain some knowledge, because COVID (and our government officials) are still out there lurking around, and if you’ve never had it, or had the shots, you may not be so lucky in a few weeks, months or years. Forewarned is forearmed.
McCullogh Base Spike Protein Detoxification Protocol to Handle the Problem:
Attack the base spike protein with Nattokinase and Bromelain to break down the spike protein and allow the body to clear it
Manage inflammation with Curcumin, another natural substance,
Hydroxychloroquine doesn’t break down the spike protein; neither does Ivermectin, Prednisone, colchicine, nicotine, nor low-dose naltrexone.
All the things that you’ve tried for long COVID are just managing symptoms, and not managing the problem.
What do we know about natural immunity? Based on a study of over 59,000 prisoners and over 16,000 staff, once you are through Omicron and Delta variants, if you have had COVID before, the next SARS-COV-2 infection has zero risk of hospitalization / death.
New Risk Stratification:
CONCLUSIONS:
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